MUVIH

Prompt

1.3.1.1

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. dihydrouracil dehydrogenase (NAD(+)).

AI Generated Sequence

500 AAs

MAKLSINFAGIKSPNPFWLASAPPTDKAYNVRRAFEAGWGGVVWKTLGSDGPPVVNVNGPRYGALWGADRRLLGLNNIELITDRPLEVNLKEIKQVKADWPDRALIASIMVPCEEQAWKAILPLVEETGADGIELNFGCPHGMSERGMGSAVGQVPEYIEMVTRWCKQYTRMPVIVKLTPNITDVKKPAAAAKAGGTDAVSLINTINSITSVDLDTFAPNPTIDGKGSHGGYCGPAVKPIALNMVAEIARDPETRGLPISGIGGVTTWKDAAEFMTLGCGNVQVCTAAMTYGFKIVQEMISGLEDWMASKGHRSVDDMIGRAVPNVTDWQYLNLNYITKARIDQDACIKCGRCHIACEDTSHQAITMVEDGVRHFEVIDEECVGCNLCVNVCPVEDCITMRPLAAGTVDERTGKVVDPYANWTTHPRNPFATAVAEFGGDLTAVTQADGPLKRFTWKGYPDVSPEWTTTPHVPGGLTGPDCPVAATNVAPLNVDKASAAC

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	78.6
NLMSIM	75.0
AACOMP	92.3
Seqdif (SeqID)	12.4 (WP_037387636.1)
Structdif (F-Target)	7.5 (1ep2 2)

ProtNLM

Name	Score
Dihydrothymine dehydrogenase	0.523
Dihydrouracil dehydrogenase	0.454
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA	0.008
Dihydropyrimidine dehydrogenase subunit B	0.005
1.3.1.1	0.001
1.3.1.2	0.001