MUL4J

Prompt

2.7.11.10

Transferases. Transferring phosphorus-containing groups. Protein-serine/threonine kinases. IkappaB kinase.

AI Generated Sequence

725 AAs
MSRLPLLQQQTCGPWELKERLGTGGFGNVYRWQNKETNEKIAIKQCRLELSPRNKERWCLEIQIMKRLNHENVVAACDVPEEMANLRNDLPLLAMEYCQGGDLRKLLNQLENCCGMKEGTILTLLSDIGSALQYLHENRIIHRDLKPENIVLQDVEGKLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQKKYTVTVDYWSFGTMVFECITGFRPFLPNWQPVQWHEKIKQKDLKDIVVSEELNGEVRFSTHLPQPNNLNSLLVERMEKWLQLMLNWDPVQRGGTVDPTKPNCKFIALIDHILNLKLVHILNMTSKIHTYPVRPDESLHSLQARIEAETGITDSNQELLLEAGLALDPRSPATQCLSDPGVRDWDFPMVFLFDKSKVTYEGPFTSRSLPECVNYIVQDSKQQLPIFQLRKVWGEVWHYISGLKEDYNRLFQGQRAAMLNLLRYNSNLSKMKNNMVSASQQLAAKLDFFHTSIQIDLDKYSEQMAYGIASEKMLKAWREMEEEVAKIMALHTDIVELQRSPFGRRQGDMLESLEQRALDLYKQLKNRPPHDNSYSDSQEMVKIIVQTVQSFDEKVRELYGHLSKTLLGCKKIIELFPKVEAVMNSIKDAENMLMQMQAKRQREIWNLLKIACSSVRSPSSSGSMSRNTMTPQLPRNSPSDSNLHEADEVVAENCSQLSELITLLQEETKENQEMFSNDLMWKDWSLKDTLL

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT80.2
NLMSIM90.0
AACOMP91.8
Seqdif (SeqID)32.7 (XP_021237526.1)
Structdif (F-Target)9.0 (4kik B)

ProtNLM

NameScore
I-kappa-B kinase0.431
2.7.11.100.386
Nuclear factor NF-kappa-B inhibitor kinase alpha0.059
IKKB kinase0.029
Inhibitor of nuclear factor kappa-B kinase subunit beta0.024
Inhibitor of nuclear factor kappa B kinase subunit beta0.014
Designed by MP, using an AMD MI250 GPU