MUJE5

Prompt

1.14.11.66

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(9) demethylase.

AI Generated Sequence

428 AAs

MGSESESPALNPSCKIMTFRPSMEEFRDFNKYLAYMESQGAHRAGLAKVIPPKEWKPRQCYDDIDDLVIPAPIQQMVTGQSGLFTQYNIQKKPMTVGEFRRLANSGKYCTPRYLDFEDLERKYWKNLTFVAPIYGADISGSLYDEGVEEWNIARLNTILDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSILKKYGIPFDRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATLCTCRKDMVKISMDVFVRKFQPERYQLWKQGKDLYTIDHTKPTPESTPEVKAWLARRVKLNKALCRQMEVEGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.2
NLMSIM	90.0
AACOMP	86.1
Seqdif (SeqID)	6.8 (XP_012925163.1)
Structdif (F-Target)	2.6 (5a7w B)

ProtNLM

Name	Score
[Histone H3]-trimethyl-L-lysine(9) demethylase	0.641
1.14.11.66	0.169
Lysine demethylase 4C	0.053
Lysine-specific demethylase 4B	0.035
Lysine-specific demethylase 4C	0.027
Lysine demethylase 4B	0.007