MTPNK

Prompt

1.13.11.39

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. biphenyl-2,3-diol 1,2-dioxygenase.

AI Generated Sequence

301 AAs
MSIKGLYHLRIEATDMAAWREYGLDVLGMVEGKGAEPGALYLRMDDFKHRLVVVPGEHDRLLEAGWECANAEGLQDIRARLEAEGVPYKETTAEEALDRRVDEMIAFSDPSGNTLEAFHGTALEHRRVVSPYGHKFVTGEQGLGHVVLTARDDAATLHFYDTVLGFRLRDSMRYDPQLVGRPDGAPAWLHFFGCNPRHHSLAFLPMPTSRGIVHLMWEVENMDDVGLCLDRALRRKVPMSATLGRHVNDKMLSFYMKTPGNFDVEFGCEGRMVEDDDWIARESTAVSLWGHDFTVGRPAGS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.2
NLMSIM70.0
AACOMP92.1
Seqdif (SeqID)15.2 (WP_077585467.1)
Structdif (F-Target)3.7 (2zi8 A)

ProtNLM

NameScore
2,3-dihydroxybiphenyl 1,2-dioxygenase0.329
1.13.11.-0.100
Iron-dependent extradiol dioxygenase0.091
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase0.085
Biphenyl-2,3-diol 1,2-dioxygenase0.070
Extradiol dioxygenase0.060
Designed by MP, using an AMD MI250 GPU