MTPII

Prompt

1.14.19.9

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. tryptophan 7-halogenase.

AI Generated Sequence

500 AAs

MTGKIKKVVIAGGGTAGWMAAAALAKHLKPDYDITLVESEEIGTVGVGEATIPHIRLFNKLLGIDENEFMRATQATFKLGIKFENWGRLGDSYMHPFGTYGKDIWGVGFQHYWLKLKQEGHADGLWDYCMNYTAARAGKFALPLDNSPLSGLNYAYHFDASLYAKYLRSYSERRGVTRVEGKITDVVRHPDSGFIASVTLEDGRRIEGDLFIDCSGFRGLLIEQTLHTGYEDWSHWLPCDRALAVQTEKTEPITPYTRSTAHAAGWQWRIPLQHRTGNGYVYSSKFISDDEAAATLLANLDGAPLAEPRLIRFTTGRRRKFWHKNVCAIGLASGFLEPLESTSIHLIQSGIARLLALFPDRGITPALIDEYNRQTSFEFEQIRDFLILHYHATQRDTPFWRYCRTDMAIPDSLKDKIDLFRESGRVFRESDELFTVPSWYAVLLGQGIVPKGYHPLADVLPKDELAAHLRGIQGVVHRTVQQLPTHQDFLDRHCAAGIAV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	88.7
NLMSIM	60.0
AACOMP	95.1
Seqdif (SeqID)	35.3 (MDE2154726.1)
Structdif (F-Target)	2.4 (6y1w B)

ProtNLM

Name	Score
Tryptophan halogenase	0.795
Tryptophan 7-halogenase	0.127
1.14.19.9	0.030
Flavin-dependent tryptophan halogenase RebH	0.008
Tryptophan halogenase,	0.005
FADH2 O2-dependent halogenase I	0.004