MTP84

Prompt

1.13.11.15

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. 3,4-dihydroxyphenylacetate 2,3-dioxygenase.

AI Generated Sequence

332 AAs
MGKLVLAAKLTHVPSLALAVGPGHDKKGHADVVAAYAEIGRRARELGADTVLVLDYHWLVNAAFHANAQQFHGGGYTPEGFGLIDIPYQYPGNPELARHIAEAALDRGMGTRAYHPEMKGLELGYTVPLRYMCGPDGVKVVSITAGCVQLQLGFRDCYRLGEAVRRAIERSGDGKVVLLASGSLSHRFLHDPEHGERIYSLFDDVVDRRVIDLWRNGQFAEFCRTLPDYIEFCGGEGGIHDTTALLGALGYDWKGRLINGEYYAYSGTGMGNVINFAAAAAPAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT76.4
NLMSIM90.0
AACOMP83.1
Seqdif (SeqID)52.1 (WP_275352546.1)
Structdif (F-Target)10.8 (8iq8 D)

ProtNLM

NameScore
3,4-dihydroxyphenylacetate 2,3-dioxygenase0.596
1.13.11.150.233
LigB domain-containing protein0.025
3,4-dihydroxyphenylacetate 2,3-dioxygenase,0.023
Extradiol ring-cleavage dioxygenase0.009
Homoprotocatechuate dyoxygenase0.007
Designed by MP, using an AMD MI250 GPU