MTL4J

Prompt

1.14.21.5

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and the other dehydrogenated. Transferred entry: 1.14.19.68.

AI Generated Sequence

295 AAs
MKKLVVLGGGWGFAKLKKDLNKDDYQVVVVSPRNYFLFTPLLPSVATGTVESRSIVEPFRRIFGRKNVEFLKAEVKDIDTEKKNVLSKTGESFIDYDYLVIATGVQTNTFGIPGLKEHAFFLKEVHDAQAIRNHIMNAFEKAYLPETDEERKRLLSFVIVGGGPTGVEFAGELHDYVTNDLVKYYPNVVDNVKITLIEASGRILPTMPEKISQYATKEFEDRGVDVLTNSRVVKVEKDGVVFTKGKEIPTDTVIWTAGVQANPVMKDLGFPGTDQRGRKLEVDEYLRVPGVPDVF

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT93.5
NLMSIM85.0
AACOMP90.2
Seqdif (SeqID)48.4 (CAA7046946.1)
Structdif (F-Target)8.8 (5kmq C)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.514
FAD/NAD(P)-binding domain-containing protein0.147
NADH dehydrogenase0.049
Pyridine nucleotide-disulfide oxidoreductase0.015
1.6.5.30.008
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.007
Designed by MP, using an AMD MI250 GPU