MTIK6

Prompt

1.5.1.53

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase (NADPH).

AI Generated Sequence

289 AAs
MKIKEILKNKKTLLSLEIFPPKTDKGFESIYKTIDELGKLNPDFISVTYGAGGSTRERTLEVASKIQSDLGLETVAHLTCVDASKEEITDILLGYKAKGIKNILALRGDHPKEGDHFEATKGDFAYASDLVKYIKSLNPDLCIGVAGYPEGHPESKNLEQDIEHLKEKVDAGADFLITQMFFDNDKFYDFLEKARAAGITVPIIAGIMPITSAKQAKKMASLCGASIPAKFIANLEKYADNPAAVREVGIEYATEQIKDLLAAGVHGVHLYTMNKPLVAKKILEATGLL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT94.2
NLMSIM90.0
AACOMP90.9
Seqdif (SeqID)47.2 (WP_073237454.1)
Structdif (F-Target)3.7 (1v93 A)

ProtNLM

NameScore
1.5.1.200.527
Methylenetetrahydrofolate reductase0.459
Methylenetetrahydrofolate reductase (NAD(P)H)0.006
Methylenetetrahydrofolate reductase [NAD(P)H]0.005
5,10-methylenetetrahydrofolate reductase0.001
Methenyltetrahydrofolate cyclohydrolase0.001
Designed by MP, using an AMD MI250 GPU