MTIC7

Prompt

2.3.3.13

Transferases. Acyltransferases. Acyl groups converted into alkyl groups on transfer. 2-isopropylmalate synthase.

AI Generated Sequence

245 AAs
MKFDKSKYPPFVPIDLTDRTWPSKTITKAPIWSSVDLRDGNQALIPPMGLEEKLKWFKLLVKIGFKEIEIGFPSASQTEYDFTRELIEQNLIPDDVTLQVLTQSREHLIKRTFESLKGAKQAIVHLYNSTSVAQREIVFNMSKEEIKKIAVNGAKLVTELAAQYPETNIVFEYSPESFTGTELDFAVEVCNAVMEVWQPTENKAMISNLATVECATPNVYADQIEWMSRHVNNRENVIISLHPHN

Ligand/Cofactor

acetyl-CoA

CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O

Validation Metrics

PLDDT88.3
NLMSIM90.0
AACOMP91.7
Seqdif (SeqID)32.0 (WP_321037780.1)
Structdif (F-Target)6.0 (3u6w A)

ProtNLM

NameScore
2-isopropylmalate synthase0.720
2.3.3.130.128
Pyruvate carboxyltransferase domain-containing protein0.117
Isopropylmalate/homocitrate/citramalate synthase0.007
Isopropylmalate synthase0.002
Alpha-isopropylmalate synthase0.002
Designed by MP, using an AMD MI250 GPU