MT61D

Prompt

1.14.19.58

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. tryptophan 5-halogenase.

AI Generated Sequence

501 AAs

MSEIRRVVVVGGGTAGWMTAAYLARLLGRDVDVVLVESPEIGTVGVGEATVPPLYRFNRLLGIDENEFMRATGATFKLGIEFRDWGRLGDSYIHNFGTLGHDLGGCRFHQAWLRARAAGEAAPLDDFSLSRLAAENGRFAPPAPAAPRSGLSYAYHFDAGLYARYLRAYAERLGVTRVEGRIAEVEQDPEDGYVRSLVLEHGRVEGDLFVDCSGFRGLLIGEALGTGPYEDWSHWLPCDAAVAVQCETPAGGPVPYTRATARDAGWQWRIGLQHRTGNGHVYCSRHMSDDEARALLLDHLDGERLAEPRLIRFRTGRRRKHWHRNCVAVGLASGFLEPLESTAIHLIQSGIHRLVALFPDRGFDPAAAAAYNRQTEAEYDRIRDFIILHYAATERDDTPFWRHCRRMAVPASLREKIDLFRAAGERVLREGELFRAPSWLQVMLGQGLVPRDYHPLADRLPDAALAAHLARIRAHTAAAAAGMPSHADFVAQCRAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	93.1
NLMSIM	90.0
AACOMP	89.7
Seqdif (SeqID)	38.6 (WP_078033082.1)
Structdif (F-Target)	2.6 (6y1w B)

ProtNLM

Name	Score
Tryptophan halogenase	0.856
Tryptophan 7-halogenase	0.092
1.14.19.9	0.012
Flavin-dependent tryptophan halogenase RebH	0.008
Tryptophan halogenase,	0.005
FAD-dependent oxidoreductase	0.003