MSKYQ

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

498 AAs

MPTYTVTVATGSQLFAGTLDYVYLSLVGTEGCSEKQLLDKPLYNDFERGAVESYDVTCDEDLGPLQLIKVEKKRYWFPDDWYCNCITVKTPTGDYVEFPCYRWITGDEEITLREGRAKLPRDDMQQILKKHRRKELEERQKRYRWENWNPGFPMSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKALENLNIRFFHMFQSWSDFDAFEKIFWKISNTISEYVMQHWQEDVMFGYQFLNGCNPMLIRRCTELPEKFPVTNDMVGSCLERGLTLEKELEKGNIFLADYDILDGIDANTIDGTCQQYLAAPLCLLYKNANGKLIPIAIQLNQPPPPENPIFLPSDPDYDWLLAKIWVRSSDFQLHQILTHLLRTHLISEVFSIAMYRQLPAVHPVFKLLIPHVRYTLEINTKARAQLICEGGLFDKANSTGGGGHVQVMQKAMKHLTYSSLCFPDDIKRGIPNYFYRDDGLRLWEIIKKFVTEVIDFYYKSDEVVKQDPELQ

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	86.6
NLMSIM	85.0
AACOMP	92.5
Seqdif (SeqID)	26.0 (XP_048799996.1)
Structdif (F-Target)	4.9 (3v92 B)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.703
LOX5 lipoxygenase	0.148
Arachidonate 5-lipoxygenase-like	0.033
ALOX5	0.019
Arachidonate 5-lipoxygenase a	0.019
Arachidonate 5-lipoxygenase b, tandem duplicate 2	0.011