MS6W0

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

664 AAs

MPSYTLTVATGSQWFAGTYDNISLTLVGCQGSAEKQLLDRPFYDDFERGAVDYDIQCPEDLGELILVKLKEHKKWWPRDDWYCRYITVTRPDGSYVEFPCYRWIQGDEIVELREGRARLTDSDQLPLLQKHRRQELEERQRRYRWSQWMPGFPIAIDACHLRKLPDRIDFETEGNFDYTLYSAAEILRNMYNFMLQSWSSWIDFDKVIKFPWKKTMSEYVNEHWQSDEFFGYQFLNGCNPMVLQRCTKLPEKFPVTDTMVQAALTEGLQTLEEELQNGNIFVADYDLLDGIPNAKIDCGHQQYLAAPICLLKYNAQNKLPMIAIQLQNQPGPENPIFLPSDSKYDWLLAKTWVRNSDFQLHQQITHLLRTHLIAEVFAVAMHRQLPCLHPVFKLLIPHTRYTMEINITARQTLCNEGVFDAVTGGGHGMLLQVTKLMSTYDLSCIPDEIGLKALPAFYYRDDGLRLWEAIEKFISDVISVFYYSDSDVVAEDELQEWIKDIMDVGFMKGEKAGFPKCLRSRTELLEFCTMIIFTCASQHAAVNQGQLDYASWMPNAPTMQRPPPPTTKGVTLEEITDLLDPMARGCHMLVMSWLLCLQQDMLRTGLYPEHEFEEPKQKQPEMAREFMERLDDITDTISRINRKNKLPYVYYLPSPLISVENIAI

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	78.7
NLMSIM	90.0
AACOMP	93.2
Seqdif (SeqID)	50.1 (XP_048472315.1)
Structdif (F-Target)	5.5 (3v92 B)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.605
Arachidonate 12-lipoxygenase, 12S-type	0.082
ALOX12	0.047
Arachidonate 5-lipoxygenase-like	0.044
Arachidonate 12-lipoxygenase, 12R-type	0.027
Polyunsaturated fatty acid lipoxygenase ALOX12	0.021