MRO04

Prompt

1.14.14.156

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. tryptophan N-monooxygenase.

AI Generated Sequence

292 AAs
MKKKKNVVYEPSEGGGAKTVIFSLKEVGGFVSKALKVFQEKHVNMVHIESRKSKRRNSEFEIFVDCSDNREQLNEIFQSLKQADVIVSMSTDNFINKVTENYSENIPWFPKTISDLDKCNRVLMMYGPDLDAHPQKFADNVYRKRKKYFGDLAFSYKHGDPIPKVEYTEEEITKWGTVFEKLNKLYPTHACREYLKNFPELIEKCGYREDNVPQLEDVFATLKERTGFRIVPVAGYLSSRDLLSGLAYRVFHCTQYVRHSSEPLYTPEPDVCHELLGHVPLFAEPSFAQSFQ

Ligand/Cofactor

FAD

CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)O

Validation Metrics

PLDDT77.6
NLMSIM60.0
AACOMP90.9
Seqdif (SeqID)24.7 (NXG38927.1)
Structdif (F-Target)38.8 (5j6d A)

ProtNLM

NameScore
TPH1 hydroxylase0.563
TPH2 hydroxylase0.340
Tryptophan 5-monooxygenase0.015
Tryptophan 5-hydroxylase 10.010
Tryptophan 5-hydroxylase 20.009
1.14.16.20.005
Designed by MP, using an AMD MI250 GPU