MQQON

Prompt

2.3.3.13

Transferases. Acyltransferases. Acyl groups converted into alkyl groups on transfer. 2-isopropylmalate synthase.

AI Generated Sequence

488 AAs
MKNFPSKYPPFVPIDLPDRTWPDKTITKAPIWCSVDLRDGNQSLIDPMDVEQKLEFFKLLVDIGFKEIEIGFPSASQTEYDFVRTLVEKNLIPDDVTLQVLTQSREHLIKRTFESLKGAKQAIVHLYNSTSVAQRKVVFNKDKEGIKKIAVNGAKLVKDLAAKYPETNIVFEYSPESFTGTEVDYAVEVCNAVMEVWQPTPENKAIINLPATVECSTPNVYADQIEWMSRNMNYRESVIISLHPHNDRGTGVAAAELGMLAGGDRVEGTLFGNGERTGNVDIVTLALNMYSQGIDPNLDFSNMNEIVEVYERCTQMKVHPRHPYAGDLVYTAFSGSHQDAISKGMKAQEETNNPLWEVPYLPIDPQDVGRSYEAVIRINSQSGKSGVAFIIEQAYGYNLPKAMHIDFGKQVQPHMDAEGKELNSEEIYELFEKTYLPQNAPITFADYVHTNADDGVRVFEAEIKHNGETQTLSGKGNGPLSAVANALK

Ligand/Cofactor

acetyl-CoA

CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O

Validation Metrics

PLDDT89.4
NLMSIM90.0
AACOMP93.8
Seqdif (SeqID)34.4 (WP_282607528.1)
Structdif (F-Target)7.8 (3u6w A)

ProtNLM

NameScore
2.3.3.130.265
2-isopropylmalate synthase0.264
Alpha-IPM synthase0.242
Alpha-isopropylmalate synthase0.224
Pyruvate carboxyltransferase domain-containing protein0.000
Isopropylmalate isomerase0.000
Designed by MP, using an AMD MI250 GPU