MQPPU

Prompt

1.14.11.67

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(4) demethylase.

AI Generated Sequence

500 AAs
MVEKEFWRVVSAIEEDVTVEYGADIASKEFGSGFPVRDGKKRLSPEEEEYLDSGWNLNNMPVMEQSVLCHIATDICGMKVPWLYVGMCFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPGSLADQLEDVMKKLAPELFESQPDLLHQLVTIMNPNTLMSHGVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVAHYRQLGRYCVFSHDEMICKMASDAKVLDVNLASTVQKDMAMMIEEEKALREKVLKMGVLDSERMDFEFLPDDERQCIKCKTCFFLSALSCYCDPDGLLVCLSHVKDLCSCPYSKYCLRYRYPLDELYPMMNALKVRAESYNEWANRVNTALEAKIGNKKSLSFRALIEESMEKKYPNNDLFRHLRLCTQDAEKCASMAQLLLNGKQGTRYRCSGGKSQNQLTVNELRQFVRQLYALPCVLIQTPLLKDLDPRVEAFQQHSQKLLSDEIPSSKELQSLLDVSFGFDVEL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.9
NLMSIM75.0
AACOMP92.9
Seqdif (SeqID)15.2 (XP_035935507.1)
Structdif (F-Target)25.9 (5fpl A)

ProtNLM

NameScore
JmjC domain-containing protein0.484
Lysine-specific demethylase 5B0.152
Lysine-specific demethylase 5A0.055
Lysine demethylase 5B0.030
KDM5B demethylase0.029
Lysine-specific demethylase 5B-like0.018
Designed by MP, using an AMD MI250 GPU