MQ75O

Prompt

1.13.11.31

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 12-lipoxygenase.

AI Generated Sequence

663 AAs

MGPVYRVRVATGSQLFAGTDDYVYLWLVGERGESEKQLLDKPFRNDFERGAVEDYRVECPEELGDILLVKLERKHWLRDDDWYCKYITVKTPTGDYVEFPCYRWITGDEEVLLRDGRAKLPGQDTHQILQKHRDQELERQKQFYRWSSWIPQGLPSIDASCHLDDLPNDDFRESKGIDFTLSAAKEALMIRNFMELMQSSWSDFDDFKRIFGVKSNTLSEYVMHWWQEDEMFGYQFLNGCNPVLLRRCSELPEKLPVTPNMVEKSLEENLEQGNIFIADYVLLDGIPANKTIDCTQQYLAAPLCLLKFNLQNGKLPMCIQLQQPPGPENPPIFLPSDTAWDWLLAKIWVRSSDFHVHQISTHLLRTHLVAEVFCVAAMRQLPALHPVFKLLVPHFHYTLSINTIARGELICEGGLFDKVNSTGGGMVHVLQRACTDLTYSSLCLPDEIARGLDIPSFYYARDGLRVWEAIKSFVTEVVHVYYKSDEVVQRDPELQEWCQDIFVEGFMRGRDSGFPKNLQSRQELCEFVTMVIFCTCAQHAAINFGQLDWCSWMPNAPCTMRTPPPTTKGTVTIDEIMTVLPDMGRACHMGLVVWLLSRFQEDPLVLGMYQEKHFLEEPPKAAMAMFRKQLDAISDMIAERNRNKDLPYEYLKPSLIRENSVAI

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	86.1
NLMSIM	70.0
AACOMP	94.0
Seqdif (SeqID)	36.7 (NXX82506.1)
Structdif (F-Target)	3.6 (7ttk B)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.460
Arachidonate 12-lipoxygenase, 12S-type	0.118
ALOX12	0.070
LOX12 oxidase	0.032
LOX5 lipoxygenase	0.025
Arachidonate 12-lipoxygenase, 12S-type-like	0.022