MQ2C0

Prompt

1.1.1.88

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. hydroxymethylglutaryl-CoA reductase.

AI Generated Sequence

477 AAs

MSSSRIPGFYRLSPEERLAHVAEQAGLTDEEIAVLANPGALPLAQADRMIENVIGTFELPMGIATNFLINGRDYLVPMAVEEPSVVAAASYMAKLARERGGFTTDSSEPLMRAQIQIVGVADPYAARLSILAAKDEILALANARDPTLVKRGGGARDLEVHVFDTPSGPMVVVHLIVDTRDAMGANTVNTMAEAVAPLIEEITGGTVRLRILSNLADLRLARARARIPVEALATREYGGEEVIDGILDAYAFAAADPYRAATHNKGIMNGIDPVVIATGNDWRAVEAGAHAYAARSGRYTSLTHWEKDADGNLVGTIEMPMAVGLVGGATKTHPLARLSIKLLGVSSAQELAEIMVAVGLAQNFGALRALATEGIQRGHMALHARNIAVAAGARGDEIDVVAARMVAEGDIRTDRAKEVLAALRAEPAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	91.4
NLMSIM	70.0
AACOMP	82.6
Seqdif (SeqID)	25.0 (WP_159279042.1)
Structdif (F-Target)	6.3 (5wpk B)

ProtNLM

Name	Score
HMG-CoA reductase	0.421
1.1.1.88	0.275
3-hydroxy-3-methylglutaryl coenzyme A reductase	0.262
Hydroxymethylglutaryl-CoA reductase, degradative	0.028
1.1.1.34	0.005
2.3.3.14	0.001