MQ089

Prompt

6.3.2.12

Ligases. Forming carbon-nitrogen bonds. Acid--amino-acid ligases.(peptide synthases). dihydrofolate synthase.

AI Generated Sequence

505 AAs
MTDLDRLREELERLELPHQIDPSLERMRYLADRLGHPERKFPVIHVAGTNGKGSTTAMIESILAAQGLKVGLYTSPHLVRFNERIALNGEPVSEEEFVEAWQQVEPALEGELEGGQLTYFEITTAMAFLLFAREDVDVAVIEVGMGGRWDSTNVIDTPDVAVITNIGLDHQDYLGDTLESIAFQKAGIIKPGAPVVVGPQVPEAVAVIERAAREVGAPLLVVEGDFWAVMDKQGWRYSQGGRYGDLQLPLRGAHQAANAAVALAAFEFYQREGYQLSEAEVRAGLANARLPGRLQRLSGEPVLLLDGAHNPAGARALAETLAEAFGDGRYRLIVGMLNDKDVAGMLAPLLPFADYVVTALNSEPRALPAEELAAAGKALGERSVAYASLAAALDAAREAAGDDDALIVTGSFLTGEVVRLAIDGKPLPEGDRPEFVRENGWDPETPEDFEELTTLAFLDFARESGADVVVVGSFLVSEAVRLALDGPLPEGGEPVLVIPPGDDEG

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT82.1
NLMSIM80.0
AACOMP91.4
Seqdif (SeqID)51.8 (MBI5379292.1)
Structdif (F-Target)5.8 (1w78 A)

ProtNLM

NameScore
Bifunctional folylpolyglutamate synthase/dihydrofolate synthase0.461
Dihydrofolate synthase/folylpolyglutamate synthase0.117
Dihydrofolate synthase0.099
6.3.2.170.075
Folylpolyglutamate synthase0.073
Dihydrofolate synthase / folylpolyglutamate synthase0.052
Designed by MP, using an AMD MI250 GPU