MPYY7

Prompt

1.14.11.66

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(9) demethylase.

AI Generated Sequence

498 AAs

MASEDHGANPGSKIMTFRPTMEEFRNFSRYVAYIESQGAHRAGLAKIVPPKEWKPRQSYDDIDDMVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRKLANSDKYCTPRYSEFDELERKYWKNLTFNAPIYGADVNGTLYDKHVDQWNIGSLRTILDMVENESGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCDAFLRHKMTLISPLILKKYGIPFSRVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKQSVQCSCRKDMVKISMDVFVRKFQPERYKLWQAGKDSTVLDHTRPTPEASPELSEWSSLRSALKGKCLPETGEVECGDEGETKSLPKRHRIGTKRHRVCLEVPQEVSSSELFPKEELSSTQYMEVDEAPRPASPRETVVQRGQVRLPDGDYRSDSVKFEELKNVKLEEEEEEEEEAAALDLSINVSRNGVIRKQVSK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	76.2
NLMSIM	95.0
AACOMP	93.1
Seqdif (SeqID)	21.3 (XP_017898494.1)
Structdif (F-Target)	2.4 (2q8c B)

ProtNLM

Name	Score
[Histone H3]-trimethyl-L-lysine(9) demethylase	0.760
1.14.11.66	0.226
Lysine-specific demethylase 4A	0.002
Lysine-specific demethylase 4C	0.001
Lysine demethylase 4C	0.001
[histone H3]-trimethyl-L-lysine(9) demethylase 4A	0.001