MP5FT

Prompt

1.14.13.114

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 6-hydroxynicotinate 3-monooxygenase.

AI Generated Sequence

296 AAs
MKKVVVVGGGASGLEFAGELARRLGRDYDVEVLARRNHHTFQTPLLHQVATGSLEPRSIEIPYRAHARRHNVRFRLGEVTDIDRATKTVELAGGDEVAYDYLVIAVGSVQNDFGIPGVAEHAIGLKDVADAQRIRRHVLANFERAELLTDDPERRRWLTFAIVGAGFTGVELAAELHDIVRDLIPRDYPNIDPNLARITLIEAGPRILAAMPERISAYAHEKLEKMGVEVRTGAMVTEYAEDGVVLKDGTEIATDMTVWAAGIAAPFVADALGLETDRAGVLVVDPHLQVSGLDNF

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT93.6
NLMSIM75.0
AACOMP91.4
Seqdif (SeqID)53.3 (WP_132922474.1)
Structdif (F-Target)6.8 (5kmq C)

ProtNLM

NameScore
NAD(P)/FAD-dependent oxidoreductase0.309
Pyr_redox_2 domain-containing protein0.264
FAD-dependent oxidoreductase0.173
NADH dehydrogenase0.139
Pyridine nucleotide-disulfide oxidoreductase0.029
1.6.99.30.028
Designed by MP, using an AMD MI250 GPU