MORPL

Prompt

1.14.19.29

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. sphingolipid 8-(E/Z)-desaturase.

AI Generated Sequence

323 AAs
MGNRVAREDFEWVYTDQPHADRRKEILAKYPEIKTLMKPDYNLKWIVVLMVLAQLTAFYLVKDLDWKWVIFWAYVFGSCINHSMTLAIHEISHNSAFGNNKAMWNRWFGIFANLPLGLPYSASFKRYHMDHHRYLGGDGIDVDIPTNFEGWFFCTPFRKFIWIVLQPLFYAFRPLCINPKPITRLEIINTLVQLSFDVVIYYLWGVKSIFYMLAGSVLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVKKIAAEYYDNLPQYNSWIRVLYDFVMDDTISPYSRMKRQLKGDVKLD

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT87.8
NLMSIM70.0
AACOMP91.0
Seqdif (SeqID)5.3 (NWV60975.1)
Structdif (F-Target)59.2 (3m75 A)

ProtNLM

NameScore
DEGS1 desaturase0.556
Degenerative spermatocyte homolog 10.192
1.14.19.170.113
Dihydroceramide desaturase-10.064
Sphingolipid delta(4)-desaturase DES10.063
Fatty acid desaturase-10.001
Designed by MP, using an AMD MI250 GPU
EC Repo - MORPL | 310.ai