MOCO3

Prompt

1.5.1.54

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase (NADH).

AI Generated Sequence

351 AAs
MTDIRARLAAGRPVVSFEFFPPKTEAEEANLWRAVDRLEPLGPDFVSVTYGAGGSTRERTVELASRIQTETGLTPVAHLTCVRRSRAELDDALGRYWDAGVRNILALRGDPPDGMGEWVPHPEGFAHAADLVRLIRELGDFCIGVAAYPEGHPEAPSLDSDIANLKRKVDAGADFAITQFFFDNDAYWRWVDRARAAGIDVPIIPGIMPITNFKQATRMASLCGATIPDWMAARLAKLDDDPAARRIGVAIATEMCRRLIAAGVRGCHFYTMNRSELATEICHLLGLRPRPAAVAAAAAAPAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.8
NLMSIM60.0
AACOMP80.2
Seqdif (SeqID)39.1 (MBX6369950.1)
Structdif (F-Target)4.1 (1v93 A)

ProtNLM

NameScore
Methylenetetrahydrofolate reductase0.501
1.5.1.200.483
Methylenetetrahydrofolate reductase (NAD(P)H)0.009
Methylenetetrahydrofolate reductase [NAD(P)H]0.002
5,10-methylenetetrahydrofolate reductase0.002
Methenyltetrahydrofolate cyclohydrolase0.000
Designed by MP, using an AMD MI250 GPU
EC Repo - MOCO3 | 310.ai