MOCKA

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

667 AAs

MPSYTVTVATGSQWFAGTDDYIYLSLVGTQGCSERHLLDKPFYNDFERGAVDSYDVTCDEDLGEIQLVKIEKRKWWHDDDWYCKYITVKTPAGDYLEFPCYRWITDDGEIVLRDGRAKLPRDDTKLILKQHRRKELETRQKMYRWTEWQPGFPLSIDAWCHKDLPRDIQFDSEKGVDFLLNYSKAMENINIRFMHMFQKSWSDFADFEKIFVRISNTISEYVMEHWKEDSMFGYQFLNGCNPVLIRRCTEIPKKFPVTDEMVESFLERGLTLEQELEQGNIFIADYELLDGIDANKTDPCTQQYLAAPICLLYKNAANKIVPIAIQLNQTPGEENPIFLPTDAKYDWLLAKIWVRSSDFLVHQTISHLLRTHLIAEVFSIAMLRQLPAVHPIFKLLVPHVRFTIAINTKAREQLISECGLFDKANATGGGGHVQLVQRAMKTLTYSSLCFPEDIKKRGVDPYYYRDDGLKVWEAIKSYVTDIVVIYYKSDDAVQEDAELQAWIRDVYIYGMFGAQDSGFPKSFRTREQLTEYLTMVIFTASGQHAAVNFGQWDWCSWIPNAPCTMRTPPPTTKGVTTIEEIVDTLPDRGRSCWHLGAVWALSQFQDNELFLGMYPEEHFIEKPVKEAMTQFRKNLAAISDKIAERNQKKDLPYEYLSPDRIENSVAI

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	86.8
NLMSIM	95.0
AACOMP	93.8
Seqdif (SeqID)	18.7 (NXX82506.1)
Structdif (F-Target)	2.9 (3v92 B)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.437
LOX5 lipoxygenase	0.360
ALOX5	0.080
Arachidonate 5-lipoxygenase-like	0.019
Arachidonate 5-lipoxygenase a	0.015
Polyunsaturated fatty acid 5-lipoxygenase	0.008