MNO10

Prompt

2.1.1.13

Transferases. Transferring one-carbon groups. Methyltransferases. methionine synthase.

AI Generated Sequence

942 AAs
MKELEELVQKRILVLDGAMGTMIQKYKLTEEDFRGERFKDHPLDLKGNNDLLCITQPDIIYDIHKKYLEAGADIIETNTFNSTSISQADYGLEHLVYEMNKSGAKLAREVADEFTAKTPDKPRFVAGAIGPTNKTCSMSPDVENPAFRAITFDELVEAYKEQVRGLLDGGVDILLVETIFDTLNAKAAIFAIDKVFEELGKRLPIFVSGTIVDRSGRTLSGQTGEAFAVSVSHANMFSIGLNCALGAKQMRPFIETLSRATAAFISCYPNAGLPNTFGEYDETPEMTAHHIKEFVEEGLVNIVGGCCGTTPAHIRAIAEAVKKHKPRVLPAIYENMLLSGLEPFVIRPETNFVNIGERCNVAGSRKFAKLIKNKNYEEALSIAKQQVEDGANILDVNMDDGMLDGEAAMTKFLNLIASEPDIARVPICIDSSNFEVIEAGLKCTQGKCIVNSISLKEGEEEFLKKATLVKKYGAAVVVMAFDEQGQATTEERKIEICSRAYHILVEKVGFNPQDIIFDPNILTIATGMEEHNNYAVDFIEATRWIKENCPGAHVSGGVSNISFSFRGNDMIREAMHSVFLYHAIKAGMDMGIVNPATLPVYEDIPKELLELVEDLIFNRRPDATERLIEYAENTKGKGKQVVQKDEWREGTVEERLAHALIKGIYTEIVEDTEEARQKYPRSLNVIEGPLMDGMNVVGDLFGAGKMFLPQVIKSARVMKKAVAHLIPFMEEEKEEVKQSNGTIVLATVKGDVHDIGKNIVGVVLGCNNYEVIDLGVMVPCEKIIQTAIEEKVDIIGLSGLITPSLDEMVFVAKEMERLGMNIPLLIGGATTSKTHTAVKIAPRYSAPVVHVLDASLNVGVCANLLDPENKDAFIEKINEEYEQLRQDHASLKKDRKYLSLEQARKNKLHIDWSSPHPVKPTFLGIREFKNYDLTELVRYIDW

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT87.6
NLMSIM70.0
AACOMP93.6
Seqdif (SeqID)28.5 (XP_012864834.1)
Structdif (F-Target)2.9 (4ccz A)

ProtNLM

NameScore
5-methyltetrahydrofolate--homocysteine methyltransferase0.423
Methionine synthase0.336
2.1.1.130.236
Cobalamin-dependent methionine synthase0.001
Vitamin-B12 dependent methionine synthase0.000
Metionine synthase0.000
Designed by MP, using an AMD MI250 GPU