MNFOY

Prompt

1.1.1.62

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 17beta-estradiol 17-dehydrogenase.

AI Generated Sequence

317 AAs

MATTTKVVLNNGHKMPILGLGTYQASPEGAEAAVKWAIDVGYRHIDCAYDYANEKEVGQAIQKAIAEGTVKREDIFVTSKLWNTFHERPLVEPACRKTLDDLQLDYVDLYLIHWPVAFKPGAELLPKDENGKAIISDIDIAATWEAMELVKDAGLTKSIGVSNFNCRQIREILNKAGITVKPVVNQVECHPYLTQEKLLEFCKSKGIVVTAYSPLGSQSRPVLENDPVLLEDPVLNAIAAKHKKTPAQVALRWGVQRGVVVIPKSVTPERIAENFQVFDFELTDEDMKTIDGLNKNWRFCVPDFWIGDKPYVFPSEY

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	91.1
NLMSIM	60.0
AACOMP	93.4
Seqdif (SeqID)	35.6 (NXL79274.1)
Structdif (F-Target)	2.5 (2pdw A)

ProtNLM

Name	Score
Aldo_ket_red domain-containing protein	0.555
Aldose reductase	0.038
Aldose reductase-like	0.033
Aldo-keto reductase	0.021
Aldo-keto reductase family 1 member B7-like	0.012
Alcohol dehydrogenase [NADP(+)]	0.011