MNAP5

Prompt

1.3.1.1

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. dihydrouracil dehydrogenase (NAD(+)).

AI Generated Sequence

815 AAs
MADLSVNFAGIKISNPFRLASSPGTKEYSVVQRAFEAGWGGVVWKTLGEEPPVLNVNSDRYSHALGADRGALGFRNIELITADRPQKNLKEIKQVKRDFPTRNVIHSLMVMCKEESWKNILPLVEDAGVPCDIECFGCPHGMTSEGMGANVGQLPEYIEMVTAWCKQTYRMPIFVKLTPNITDIHVPARAAAKGGADAISAINTINSMLSVDLDIFKEEPWIGGKSSHIGYKGPAVKPIALQNFVEIARDPEAINLPISGLGGITTWRDLAEFIALGCGNVQVCTAAMTYGFRIVQEMIDGLSNYFDKGVGHSSSDKFGMACPNPVSWLHSLNIVYLGRANTFDACATSGRCHIARVDGYQRKGFTSMRAVPEEVEVVEKEVCKFLPLLSVPKKVIMNGRVEAMGKFEERETDEGNEWKEDEDTVVRLPANFIISAFGSILDDPTVKEALQKVFKDRWGLPEVDPTMQTSEPWVAFTGGDIAGAYNTTVENVNDGKQASWYIHMQIQSMYGVSIEKPELPELFPTIDQVDISVEMAGMKIFPNTGLASATPATSTTAMRRAFEAGWGFALTKTFSLDKDIVTNVSPKIVRGTTSGPFYGPQGGSFLNIELISEKIAEYWQCSVTELKADFPNHIVIASIMCSYNKDDWTELSKMAEDAGADLEINLSLCKHGMSERGMGLACGQDPELVRNICWVVRQAVTIPFFAKLTPNVTDVIAIARAAHEGGADGVTATNTVSGLMGLKADGTPWPAVGRRGTTTYGGVSGNTIRPIALRAVSAIARSIPGFPILATGGMDSAETGSQFLHAGASVLQVCS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT72.8
NLMSIM70.0
AACOMP94.8
Seqdif (SeqID)45.3 (NXC27221.1)
Structdif (F-Target)9.4 (1ep2 2)

ProtNLM

NameScore
Dihydrothymine dehydrogenase0.504
Dihydrouracil dehydrogenase0.436
Dihydropyrimidine dehydrogenase [NADP(+)]0.019
1.3.1.20.012
DPD0.004
DHPDHase0.004
Designed by MP, using an AMD MI250 GPU