MNA9J

Prompt

1.14.11.66

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(9) demethylase.

AI Generated Sequence

247 AAs
MASAEHPQPNPSKIMTFRPTSEEFRDFNRYIAYMESQGAHRAGLAKIVPPKEWKPRGSYDDIDDLVIPAPIQQVVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYTEFEELERKYWKNLTFNSPIYGADVNGSLYDKHVDEWNIGRLRTILDMVEEESGITIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYCIPPEHGRKLERLAKGFFPGSAQSCDAFLRHKMTLISP

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT83.8
NLMSIM70.0
AACOMP92.2
Seqdif (SeqID)9.2 (XP_023582905.1)
Structdif (F-Target)7.6 (2w2i C)

ProtNLM

NameScore
Lysine-specific demethylase 4B0.222
Lysine-specific demethylase 4D0.159
Lysine (K)-specific demethylase 4B0.099
Lysine-specific demethylase 4D-like0.086
KDM4B0.060
Lysine-specific demethylase 4B-like0.046
Designed by MP, using an AMD MI250 GPU