MN2HO

Prompt

1.1.1.189

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. prostaglandin-E2 9-reductase.

AI Generated Sequence

394 AAs

MATKRIVLKLARPGNGEPVAENFRLEEVELPDEIGEGQVRLRTLYLSVDPYMRCRMNEDVGTYLTPWELGEAVEGGGIGVVEESKHPGFAKGDLVLSFNWPWQTKAILDGNGLEKVDLQLVDGHLSYFLGAVGMPGLTALAGIKEIGHAKAGQTMVVSGAAGAVGSLAGQIGKLEGCSRVVGIAGGDEKCAILTEELGFDVAINYKVGDVAEQLREACPEGIDVYFDNVGGDISDAVISQMNEFGHIILCGQISQYNKDTPYPPPLPPEIMAKQRITRERFIVMDYMDRFEPAILQLTQWVKEGKLKVKETIVDGIENMPGAFQSMMTGGNIGKQIVKVSDEALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	87.2
NLMSIM	70.0
AACOMP	88.3
Seqdif (SeqID)	25.5 (XP_029807322.1)
Structdif (F-Target)	3.4 (2w98 A)

ProtNLM

Name	Score
15-oxoprostaglandin 13-reductase	0.248
1.3.1.74	0.237
Prostaglandin reductase 2	0.136
1.3.1.48	0.134
PKS_ER domain-containing protein	0.040
NAD(P)H-dependent alkenal/one oxidoreductase	0.028