MMVZW

Prompt

1.1.1.189

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. prostaglandin-E2 9-reductase.

AI Generated Sequence

392 AAs

MTTRVVLDLPARPDGVPVADNFRLETVDLDPAVADGQVRVRTLYLSVDPYMRARMNEDGSSYLPPWAVGETVAGGAIGVVEASRHPAFAPGDFVTNFWPWQTHAVLDGAGLEKVDPQLDGHPLSYLAGIAGMPGLTAYAGLLDVGARPGGTMVVVSGAAGAVGSLVGQIGRIRGCARVVGIAGGDEKCAWLTAELGFDAAIDYKTGDFAAELRRACPDGVDVYFDNVGGDVLDAVIAQMNEHSRIVLCGQISQYNRDVPPPPPPPEAIAERNLRTREFGVVMHYDRYEPGILELSRWIAEGKLKYRETVVEGLENMGEAFMGLMRGANIGKQIVSVADEAVEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.7
NLMSIM	70.0
AACOMP	84.6
Seqdif (SeqID)	40.0 (XP_006884754.1)
Structdif (F-Target)	4.9 (2w98 A)

ProtNLM

Name	Score
NADP-dependent oxidoreductase	0.433
PKS_ER domain-containing protein	0.172
1.3.1.74	0.053
1.-.-.-	0.022
Oxidoreductase YncB	0.020
1.3.1.-	0.020