MMLGC

Prompt

6.3.2.51

Ligases. Forming carbon-nitrogen bonds. Acid--amino-acid ligases.(peptide synthases). phosphopantothenate--cysteine ligase (ATP).

AI Generated Sequence

227 AAs
MKILITSGGCTEKIDQVSRITNHSSGLGKNIITETYLAAGHEVTLITTKNALKPEHQPNLTIREITNVDELLTEMKPLVKEHDVLIHSMAVSDYTPVEMTGLEPVQASSNLAEFIKKNKNTEKISSNDYVQLVFLKKTPKIISLIKSWNPAIQLIGFKLLVDVSYDELVDVARSSLKNKGAQCIIANDLTQIANQQHRAYLVDKAQLKTAKTKEEIALLLKKIQAQY

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT92.6
NLMSIM90.0
AACOMP89.6
Seqdif (SeqID)30.1 (WP_293951811.1)
Structdif (F-Target)5.7 (2gk4 A)

ProtNLM

NameScore
Phosphopantothenate--cysteine ligase0.567
6.3.2.50.249
Coenzyme A biosynthesis bifunctional protein CoaBC0.064
Phosphopantothenate-cysteine ligase0.043
Phosphopantothenoylcysteine synthetase0.017
DFP domain-containing protein0.016
Designed by MP, using an AMD MI250 GPU