MME60

Prompt

6.5.1.8

Ligases. Forming phosphoric ester bonds. Forming phosphoric ester bonds. 3'-phosphate/5'-hydroxy nucleic acid ligase.

AI Generated Sequence

297 AAs
MTEEEIKKLREEINKYNYAYYVLDAPEISDYEYDQLFDELQALEAAHPELVLPDSPTQRVGAGPLKGFKKVAHAVPMLSLDKAFSVEELREWHERVFKVLGEDVEYLCELKIDGAAISLTYENGVLVRAATRGDGVVGEDVTANARTIKSIPLKLKGEPPEILEVRGEVIMPLKAFEKLNAEREAAGKLYANPRNAAAGSVRQLDPSITAARPLSMFAYQVGEVSGLAFKTHQEVLDWLKGLGFKVIPLLKLCKSLEEVIAFYEHWHTHRDSLDYDIDGVVIKVDDLAYHEELGTTV

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT85.1
NLMSIM60.0
AACOMP92.5
Seqdif (SeqID)38.6 (MCL6554486.1)
Structdif (F-Target)12.3 (3bac 2)

ProtNLM

NameScore
LIGANc domain-containing protein0.293
NAD-dependent DNA ligase LigA0.283
6.5.1.20.175
DNA ligase (NAD(+)) LigA0.145
DNA ligase0.064
NAD-dependent DNA ligase (Contains BRCT domain type II)0.007
Designed by MP, using an AMD MI250 GPU