MMDHT

Prompt

2.1.1.13

Transferases. Transferring one-carbon groups. Methyltransferases. methionine synthase.

AI Generated Sequence

668 AAs

MEEAGAQVLDINMDDGLLDGPAAMTRFKCLIASEPEIAKVPLCIDSSKFSVIEAGLKQCQGKCIVNSISLKEGEDAFLEKARKIKKYGAAVVVMAFDEEGQATEIERKVEICQRSYHILTEKVGFNPNDIIFDPNILTIGTGMEEHNNYAVDFIEATKWIKETCPGARISGGVSNLSFSFRGNARIREAMHSVFLYHAIKAGLDMGIVNAGSLPVYEDIPKELLQLCEDLIWNRNPDATERLIRYAETNKAEGKKVVQTDLWREGTVPEERLAYALIKGITEYVEEDTEEARQNYPRPLNVIEGPLMNGMNVVGDLFGAGKMFLPQVIKSARVMKKAVAHLIPFMEAEKEREAAQGYGQIVLATVKGDVHDIGKNIVGVVLGCNNYRVIDLGVMVPCDKILQAAIEHKADIIGLSGLITPSLSEMIYVAKEMERLGLKTPLLIGGATTSRTHTAVKIAPAYSAPVVHLADASQSVVVASDLLNENLKDDFFEEILHEYDQIRQDHAESLKDRRYLTLEQARKKGLHIDWSSHPPVKPTFLGTRVFENYDLEKLVPYIDWGPFFDVWQLRGRYPRIFNDPKYGPEAKRVYADAQNLLEDIIAKEKLLRVSFREGSVEECEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT	82.9
NLMSIM	90.0
AACOMP	89.3
Seqdif (SeqID)	23.5 (XP_043818516.1)
Structdif (F-Target)	15.1 (3k13 B)

ProtNLM

Name	Score
5-methyltetrahydrofolate--homocysteine methyltransferase	0.371
Methionine synthase	0.363
2.1.1.13	0.258
Cobalamin-dependent methionine synthase	0.001
Methionine synthase (B12-dependent)	0.000
2.5.1.15	0.000