MMDGR

Prompt

1.1.1.88

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. hydroxymethylglutaryl-CoA reductase.

AI Generated Sequence

500 AAs

MTVSGRLPGFRSLSPEERLALLAELAGLSDEQRALLASPGALPLQVADRMIENVIGTFELPLGLALNFQINGRDVLVPMATEEPSVVAAASNMAKVAREGGGFRASSSEPLMIGQVQVVNVGDPFAARERLLAAREEILRLANSHDPSLVKLGGGARDIEVHVFPTESRGPMVVLHLIVDTRDAMGANTVNTMAEAVAPLIEEITGGRVRLRILSNLADRRLARARARFPVEALAGGERGGEEVIRGILDAYTFARVDPYRAATHNKGIMNGIDPVILATGNDWRAVEAGAHAYAARSGRYTSLTRWEKDAEGDLVGTIEMPMAVGLVGGATKTHPLVQLSLKILGVNSARELGEIVAAVGLAQNLAALRALATEGIQRGHMALHARSIAVAAGATGEEIDAVARRMVEAETHRLDRAERLLAELRGEKPAEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.4
NLMSIM	85.0
AACOMP	87.5
Seqdif (SeqID)	25.1 (WP_077034819.1)
Structdif (F-Target)	4.5 (4i4b A)

ProtNLM

Name	Score
HMG-CoA reductase	0.399
1.1.1.88	0.308
3-hydroxy-3-methylglutaryl coenzyme A reductase	0.252
Hydroxymethylglutaryl-CoA reductase, degradative	0.028
1.1.1.34	0.003
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase	0.000