MLZET

Prompt

1.3.1.74

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. 2-alkenal reductase [NAD(P)(+)].

AI Generated Sequence

331 AAs

MTTKQAWVLKDRFPGFPTDSNFKLETVDLPDLKNGEVLLETLYLSVDPYMRPFMRKPMKVGETMRGGQVAKVVESKNPAFKAGDYVVGNFGWRTYSVIDGKDLVKVVPDWQDHLPLSLALGTLGMPGLTAYFGLLDIGCPKEGETVLVSAAAGAVGSMVGQIAKIKGCRVVGIAGSDEKVAYLKELGFDEAFNYKTVESLDEALKAAAPDGYDCYFDNVGGEFSNAVIAQMNPFGRIAVCGAISQYNDTPPPPGPRPLPQVILKRLRMEGFIVMRWHDRWPEGLEQLMGWVKEGKIKYREHVTEGLENAPEAFIGMLKGENIGKALVKVAE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	90.3
NLMSIM	85.0
AACOMP	92.6
Seqdif (SeqID)	34.3 (XP_009571593.1)
Structdif (F-Target)	3.0 (1v3t B)

ProtNLM

Name	Score
1.3.1.74	0.198
NAD(P)H-dependent alkenal/one oxidoreductase	0.176
Dithiolethione-inducible gene 1 protein	0.158
15-oxoprostaglandin 13-reductase	0.137
Prostaglandin reductase 1	0.135
Leukotriene B4 12-hydroxydehydrogenase	0.122