MLXMS

Prompt

1.13.11.6

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. 3-hydroxyanthranilate 3,4-dioxygenase.

AI Generated Sequence

340 AAs
MPIPLPFNFPKWIEDNKHSLFPPVCNKLMWDDTQLVVMFVGGPNERTDYHIEEGEEFFYQVKGDMCLKVMENGKFRDVHIKEGEMFLLPARVPHSPQRPANTIGLVIERKRPAHETDGLRWYCENCNEVLHEAWFHCEDLGTQLKPVIHEFYNSEEYKTCKPNPDHLLKEDPFKPINTTVMKPFSFEAWLNDHRKEIKKRKSVSMFGENFYTEVVAYGPGPTEKSKKNTDTWIWHLEGTSTVTMDGKTLTLSAGDSLLVRTQTGYVWKRAGEVVCLSIAQDGPKREFPEEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT89.0
NLMSIM85.0
AACOMP80.8
Seqdif (SeqID)26.7 (XP_054052230.1)
Structdif (F-Target)3.3 (5tkq A)

ProtNLM

NameScore
HAD0.270
3-hydroxyanthranilate 3,4-dioxygenase0.191
3-hydroxyanthranilic acid dioxygenase0.152
3-hydroxyanthranilate oxygenase0.137
1.13.11.60.121
3-HAO0.108
Designed by MP, using an AMD MI250 GPU