ML5B6

Prompt

1.14.19.17

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. sphingolipid 4-desaturase.

AI Generated Sequence

322 AAs
MGNRVGRNDFEWVYTDEPHTQRRKEILAKYPEIKTLMGYDPHLKWIVLGMVFLQLLACYLVKDLSWKWIFFWAYAFGGCINHSLTLAIHDISHNVAFGNKQAKWNRWFAIFANLPIGIPYSASFKKYHVDHHRYLGGDSLDVDIPTDFEGWFFCTPLRKFLWFILQPLFYALRPLYVNPKAITRMEILNALVQLSVDLAIYYLWGLKPIVYLIAGSILCMGLHPISGHFIAEHYMFLKGHETYSYYGPLNWLTFNVGYHMEHHDFPSIPGCRLPLMKKIAAEYYDNLPHHNSWVRVLWDFVFDDTLGPYSRVKRLCKLAKDS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT85.3
NLMSIM85.0
AACOMP90.9
Seqdif (SeqID)7.8 (NXH67976.1)
Structdif (F-Target)32.3 (8f6t A)

ProtNLM

NameScore
DEGS2 monooxygenase0.977
1.14.19.170.015
Sphingolipid 4-desaturase0.004
Degenerative spermatocyte homolog 20.001
Dihydroceramide desaturase-10.000
Delta 4-desaturase, sphingolipid 20.000
Designed by MP, using an AMD MI250 GPU