ML3NL

Prompt

1.14.11.66

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(9) demethylase.

AI Generated Sequence

439 AAs
MGSESVYAPNPGCKIMTFRPTMEEFGDFNRYLAYIESKGAHRAGLAKVIPPKEWKPRQCYDDIDDLVIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEYRQLANSDKYCTPRYQDFEDLERKYWKNLTFVAPIYGADINGSIYDEDVAEWNIGRLNTILDMVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAVPPEHGKRLERLAQGFFPGSSQSCDAFLRHKMTLISPSILKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAVLCTCRKDMVKISMDVFVRKFQPERYKLWKAGKDLTVIDHTRPTPESAEFLKAWELQRRKVKAAALRQFGVEEGTPKKRKEEEEEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT87.6
NLMSIM90.0
AACOMP89.4
Seqdif (SeqID)10.5 (XP_044795834.1)
Structdif (F-Target)2.2 (5a7w B)

ProtNLM

NameScore
[Histone H3]-trimethyl-L-lysine(9) demethylase0.772
1.14.11.660.170
Lysine demethylase 4C0.008
Lysine demethylase 4B0.006
Lysine-specific demethylase 4B0.005
Lysine-specific demethylase 4D0.004
Designed by MP, using an AMD MI250 GPU