ML0P6

Prompt

1.14.12.17

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor. nitric oxide dioxygenase.

AI Generated Sequence

296 AAs
MSKKKVVVVGAGWVGLGRALKTLGKAKYDIMLVSARNYHTFWTPMLHSVAGGALEAHAIVEPIRRIVHRSKGHFHFQGAMCHKIDKANKIVQAEQFVGEDGEEVSLDYLVAVALGSVNTFHGTPGLENACYFLKEVADARRIERNIMNCFEKSDPTCDEEKKKRLTFVVVGAGATGVELAGALADFRKELKAYVPRVLKDNMKITLIEASRSILPMFDERSIKYAVEELKKRGVEVLLTNAVTSVEDDKVGFKDGEFIPADMLVWAAGVGSPFVCKMLPGLEQTHRGQLVVDPHLQ

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT87.3
NLMSIM70.0
AACOMP92.8
Seqdif (SeqID)59.9 (XP_019193890.1)
Structdif (F-Target)10.7 (5kmq C)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.912
FAD-dependent oxidoreductase0.016
FAD/NAD(P)-binding domain-containing protein0.015
NAD(P)/FAD-dependent oxidoreductase0.007
NADH dehydrogenase0.006
Pyridine nucleotide-disulfide oxidoreductase0.005
Designed by MP, using an AMD MI250 GPU