MKNZ8

Prompt

1.1.1.181

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase.

AI Generated Sequence

419 AAs

MAGKYLVTGGSGFLGQHIVRLLVEREDLEEIRVFDLKFPEELKEEFQKLQPTTVTFVQGDIRDEKCLKAACQGISCVIHTASIIDVMGVIPRETILKVNVKGTQNLLEACVQSGVAHFVYTSTAEVAGPNYIPQNGDETLPYAETHWAPYPYTKAMAEQAVLAANGTWAKNGGTLHTCALRPTGIYGEGDPLLLPGLTRALKNNKLKLIQGKSSLVDPVYVGNAAWAHILAARALRDPKAAHIQGQAFYINDDTPHQSYDALNTTLLKGLGCERPSRMTLPYALMYWIAFLLETVSFLLGPYVNYQPTFNRHLVTLTNTTFTFSIKKARRDLGYKPAVSLEEGKQRTIEWIGHLVERHRGKLDKTLLGRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	84.9
NLMSIM	85.0
AACOMP	87.3
Seqdif (SeqID)	36.0 (XP_027426466.1)
Structdif (F-Target)	8.9 (6kvc 2)

ProtNLM

Name	Score
3Beta_HSD domain-containing protein	0.636
Short-chain dehydrogenase/reductase family 42E member 1	0.029
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0.019
3-beta hydroxysteroid dehydrogenase/isomerase	0.014
Steroid Delta-isomerase	0.014
Hydroxysteroid dehydrogenase	0.010