MKH7U

Prompt

1.3.1.88

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)].

AI Generated Sequence

366 AAs

MRIGLAPMEGLVDDVLRDVLTRVGGFDWCVTEFVRVTDRLLPPRVFHRYAPELTHGGRTPAGTPVRVQLLGSDPEWMAENAALAAELGAHGIDLNFGCPAKTVNRSGGGAVLLKEPELLHRIVAEVRRAVPAHIPVSAKMRLGFDDPDRALDCARALEAGGASEIVVHARTKVDGYKPPAHWEWIARVREAVPVPVVANGEVWTVDDWRRCREVSGCDDVMLGRGLVARPDLARQIAAARAGEPAPEMPWAELLPLLRDFARWREARLDPRHAAGRLKQWLAYLTRNYPEAVELFAEIRRLTDPARIAALLAEVGVAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	94.8
NLMSIM	85.0
AACOMP	81.4
Seqdif (SeqID)	23.3 (WP_041770195.1)
Structdif (F-Target)	3.0 (4yco B)

ProtNLM

Name	Score
1.3.1.-	0.266
TRNA-dihydrouridine synthase C	0.235
TRNA-dihydrouridine(16) synthase	0.196
U16-specific Dus	0.172
U16-specific dihydrouridine synthase	0.116
Dus domain-containing protein	0.002