MK486

Prompt

1.1.1.357

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 3alpha-hydroxysteroid 3-dehydrogenase.

AI Generated Sequence

351 AAs
MENLKELFKENGIRVIGGDGSGIGKAFAYELARRGYNVILVSRNLEKLEEAAKEIEKETGKKVVAIKADFSDEESVYKLIEETLKEFGGIDILVNNAGLMLPKSLEDMTLEDIEQVMDVNVKGVLNCTQAVLPLMKKRKSGRIINISSVAGLIGYPGQSAYCASKFAVIGFSECLARELAGKGIIVNTIAPYAVKTDMTGNLRPDTKESITEEYVGPEDAAETIYYLLSNQGSSYNGEMFVPGLRISRMGGFITRRLKLYADFIKRCWDKVHKKLQKGGFPLTEEQTKEMLKSVFDGLSSGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT80.8
NLMSIM85.0
AACOMP82.4
Seqdif (SeqID)55.2 (NLI92295.1)
Structdif (F-Target)5.8 (7djs A)

ProtNLM

NameScore
SDR family NAD(P)-dependent oxidoreductase0.192
SDR family oxidoreductase0.166
Short-chain dehydrogenase0.101
1.1.1.1000.082
Short-chain dehydrogenase/reductase SDR0.051
3-oxoacyl-ACP reductase0.042
Designed by MP, using an AMD MI250 GPU