MJD6H

Prompt

1.1.1.187

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. GDP-4-dehydro-D-rhamnose reductase.

AI Generated Sequence

744 AAs

MKILITGANGQLGWELAQLARDRGLEVVALSRDELDITDPAAVARAIREIRPDVVVNAAAYTAVDKAESEPELAWRVNAEGPANLAAAAAEAGATLIHISTDYVFDGTGGTPYREDDPTTPLSVYGRSKLAGEEAVRASGARHAILRTSWVYGEHGRNFVKTMLRLAEEREELSVVADQFGCPTYAADLADATLRLIERRLDDPATGVYHFANEGVTTWYDFARAIFERAGLRGDVRIPRIATEDYPTPARRPANSRLDGAKLTEAFGLTPRDWRDGLARLLPELDGRRPERIELPEGRTVLLGGRDGRLVGELAGLLGDRGLDLVVNAAAYTAVDKAESDPELAWRVNAAGPAHLAALAAERGARLVHVSTDYVFDGTPGTPYREDDPTPNLSVYGRSKLAGEEALVRENGPDHAIVRTAWVYGELGGRNFVKTMLRLAERRERLVVVADQIGSPTPYAEDLADACLALVRERGLDLVVAAAAYTDVDKAESEEPELAWRVNAVGPAHLAALAAERAGARLVHVSTDYVFDGRPGEPYREDDPTPNLSVYGRTKLAGEEALVRETGARHAVILRTSWVYGELGGHNFVKTMLRLAEERERLSVVADQFGRPTPYAADLADAVLHLVAERRGDGRLVHLAANEGTSWHDFARAVFEAAGLDLPEGRVLHLANEGASTWHDFARAVFEAARRLGLDPERVRPVATAEYPTPARRPAYSRLDGEKLRETFGIRLPDWREGLARLLG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	77.1
NLMSIM	70.0
AACOMP	89.2
Seqdif (SeqID)	41.0 (TVR63639.1)
Structdif (F-Target)	3.8 (1vl0 B)

ProtNLM

Name	Score
DTDP-4-dehydrorhamnose reductase	0.591
1.1.1.133	0.380
DTDP-6-deoxy-L-mannose dehydrogenase	0.011
DTDP-L-rhamnose synthase	0.007
DTDP-4-keto-L-rhamnose reductase	0.002
DTDP-6-deoxy-L-lyxo-4-hexulose reductase	0.002