MJ8AH

Prompt

1.13.11.39

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. biphenyl-2,3-diol 1,2-dioxygenase.

AI Generated Sequence

303 AAs
MAIKSLGYMRLETTDMDAWREYGLKVLGMVEGKGADEAALYLRMDDFRHRLVVVPGEHDRILTVGWEVANAEQLDQIRARLEAAGVTYKEASAAEALDRRVDEMITFSDPSGNTLEVFHGPALDHRPVVSPYGHRFVTGDQGLGHVVLPTADDAAALHFYTDVLGFRLRDSMRLPPQVPGRADGPRVAFLFHGCNPRHHSLAFLPMPSPSGLIHLMLEVETLDDVGLALDRALRRKVPISATLGRHTNDKMLSFYMKTPGNWDIEFGCEGMRVDDRTYTAREITADSYWGHDFTVGMAPGMTT

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT89.4
NLMSIM70.0
AACOMP92.4
Seqdif (SeqID)22.6 (WP_057362638.1)
Structdif (F-Target)4.9 (2zi8 A)

ProtNLM

NameScore
2,3-dihydroxybiphenyl 1,2-dioxygenase0.286
Biphenyl-2,3-diol 1,2-dioxygenase0.162
1.13.11.390.097
Extradiol dioxygenase0.091
1.13.11.-0.085
Iron-dependent extradiol dioxygenase0.063
Designed by MP, using an AMD MI250 GPU