MJ4Y3

Prompt

1.14.21.11

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and the other dehydrogenated. Transferred entry: 1.14.19.72.

AI Generated Sequence

212 AAs
MKKVVVIGAGSGGLECALRCLQKGLKPKTKFEQVRDRNGHLTWKHWLPERASGTIESKVISQPFRMTLFSDFPFEHYPSYMDHINIYQKYIKLAEHKDLALDYLVFATGCSHNTFHWPGWEKQSTFLTESNDAQLIRSQVLQMFATGIHTRPLNEEAKLPGIKFIVGGGFTGLELAGELPEFVKRVLVVGLGNITTDLIKVSLVEAQRVLPS

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT82.2
NLMSIM85.0
AACOMP93.6
Seqdif (SeqID)67.1 (WP_144407712.1)
Structdif (F-Target)20.2 (5na4 A)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.664
NAD(P)/FAD-dependent oxidoreductase0.149
FAD-dependent oxidoreductase0.060
Pyridine nucleotide-disulfide oxidoreductase0.047
NADH dehydrogenase0.017
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.007
Designed by MP, using an AMD MI250 GPU