MITYO

Prompt

1.13.11.2

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. catechol 2,3-dioxygenase.

AI Generated Sequence

308 AAs
MSGKMRPGHVQIRVLDMDEALRHYELVLGLMEMDRDEDGRVYLKAWTEDKHRSVILREGPRAGMDFMGFKVVDEDKLAELRDELDSYGCEVRELPAGEEDRCGGRIRFQAPSGHQFELFYAKEYTDKWGVESNPEPAWPRDLKGMGAMRFDHCLLYLDEPETREYLFTEVLGFYLPEQIVEDPGQRLAQFFSLCTAKPHDVAFIHHPKPGKLHHVSFFLETWEDVLRAADIMSMTTTISIDIGPRHGLTRGQTIYFFDPSGNRNEVFCGGGYQTYPDHKPVTWADEVGKAIFYHDRTLLNEFLMTVSK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT80.8
NLMSIM85.0
AACOMP91.9
Seqdif (SeqID)29.0 (WP_009397178.1)
Structdif (F-Target)7.5 (1mpy D)

ProtNLM

NameScore
1.13.11.20.369
Metapyrocatechase0.228
Catechol 2,3-dioxygenase0.193
CatO2ase0.182
3,4-dihydroxyphenylacetate 2,3-dioxygenase0.002
Dioxygenase0.001
Designed by MP, using an AMD MI250 GPU