MIQAQ

Prompt

1.14.13.127

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 3-(3-hydroxy-phenyl)propanoic acid hydroxylase.

AI Generated Sequence

557 AAs
MKLQHPHHPIVIVGAGGIGGLALVTGLKKLGRKDVQVVLVSDRNYHFTKPLLPDVATGTLESRSLVDVIPALHQRWNHFRFLEGTVIDIDAEKRITLAEEGREELSLDYDLVVMAVGSQTNTFGTPGVEHNCFHLKNVEDAQRIRQNILLNCFEAASTLTDEEKRRQALNVAFVCGGGFTGVELAGELHNFVEQVLDYYKNLNPNELRISLIEAGRAILPALPESISQYAHERLTKMGVDVLLTGRMVKVSADGIHTKDGKEIFPGECTLWSAGVRPFLLKEVSQLKIRNRVLLTGDATHLRTVGDNVYAIGCDASVQDRWFQLPVPTAQAIAQQGEYLAKNIKRMADGKALHSFKYKHFGLVASIGNRSAVGALPGLVFNGLSMVWWRAMVRYMTLSMYRHRLALVGDAWKTMFGRGDVFNIVTRDEKSVHLRLANAGLFRFVVIGWRCNLWHSEDELGILQKLDRDGTKISGFEVRILQWAQNDKDGIVHLPFDLQLLKYLPHNNNAIEGNPLMRRYADRTWQQPTGQTQKNLQTLAVVALTPRHTAVYGIDLRK

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT70.0
NLMSIM60.0
AACOMP94.9
Seqdif (SeqID)57.2 (WP_218465973.1)
Structdif (F-Target)7.4 (4nwz A)

ProtNLM

NameScore
1.6.99.30.207
NAD(P)/FAD-dependent oxidoreductase0.175
NADH dehydrogenase0.140
FAD-dependent oxidoreductase0.128
Pyr_redox_2 domain-containing protein0.072
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.044
Designed by MP, using an AMD MI250 GPU