MIP0X

Prompt

1.13.11.39

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. biphenyl-2,3-diol 1,2-dioxygenase.

AI Generated Sequence

302 AAs
MSIKSLGYMRIEATDMARWETYGLDVLGMVEGKGDEPGALYLRMDDFRARLVIVPGEKDRILVSGWEVANREGLQDLRNRLDEAGTPYKEATAAEAEDRRVDEVIRFTDPSGNTLEVFHGTALVHRRVVSPYGKRFVTGEQGLGHVVLTTADDEASLHFYTDVLGFRLRDSMRMPPQMVGRPADGPARLWFFGCNPRHHSLAFMPMPTPSGIVHLMLEVETQDDVGLCLDRALRRKVPISATLGRHVNDLMLSFYMKTPGNRDIEFGCEGRQVDEDNWIERESTAVSLWGHDFTVGFKEGMT

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.7
NLMSIM70.0
AACOMP92.1
Seqdif (SeqID)18.1 (WP_293322404.1)
Structdif (F-Target)3.8 (2zi8 A)

ProtNLM

NameScore
2,3-dihydroxybiphenyl 1,2-dioxygenase0.346
1.13.11.-0.138
Extradiol dioxygenase0.118
Iron-dependent extradiol dioxygenase0.105
Biphenyl-2,3-diol 1,2-dioxygenase0.068
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase0.061
Designed by MP, using an AMD MI250 GPU