MIN85

Prompt

1.14.11.66

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(9) demethylase.

AI Generated Sequence

273 AAs
MASESDPQPNPGCKIMTFRPTMEEFRDFNKYLAYIESQGAHRAGLAKIIPPKEWKPRQCYDDIDDLVLPAPIQQVVTGQSGLFTQYNIQKKAMTVREYRQLANSDKYCTPRALDFEDLERKYWKNLTFVSPIYGADVNGALYEDDVAQWNIGRLRTILDMVEEECGTSIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAVPPEHGKRLERLAQGFFPGASQGCDAFLRHKMTLISPSVLKKYGIPFDRVTQEAGEFMITFP

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.0
NLMSIM70.0
AACOMP93.4
Seqdif (SeqID)11.4 (XP_027808390.1)
Structdif (F-Target)6.9 (2w2i C)

ProtNLM

NameScore
Lysine-specific demethylase 4B0.307
Lysine (K)-specific demethylase 4B0.133
Lysine demethylase 4B0.105
KDM4B0.056
Lysine-specific demethylase 4D0.055
Lysine-specific demethylase 4B-like0.053
Designed by MP, using an AMD MI250 GPU