MIMV4

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

667 AAs

MPSYTVTVATGSQLFAGTLDYVYLSLVGTEGCSERQLLDRPFYNDFERGAVESYDVTCDEDLGELQLIKIEKKRYWFNDDWYCNYITVKTPTGDYVEFPCYRWITGDETVTLRDGRAKLPADDQQQILKQHRRKELEERQKNYRWKNWNPGFPMSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKALENLNIRFFHMFQSSWDNFDAFEKIFWKISNTVSEYVMQHWKEDVMFGYQFLNGCNPMLIRRCTELPEKFPVTNEMVESSLERGLTLEKELEKGSIFLADYEILDGIDANTIDCTQQQYLAAPLCLLHKNANGKLIPIAIQLNQQPGPENPIFLPSDAPYDWLLAKIWVRSSDFQVHQITSHLLRTHLISEVFSIAMYRQLPAVHPVFKLLIPHVRYTLEINTKARAELISEGGLFDKAVNTGGGGHVQIVQKAMKTLTYSSLCFPDDIKARGIPNYFYRDDGLKLWEIIEKFVSEIIDFYYKSDEVVKQDPELQAWCEDITKFGLRGAEDSGFPKSFTTREELCEFVTMVIFTCSAQHAAVNFGQYDWCSWMPNAPCTMRPPPPTTKGVTIEKMFDTLPDVQRSSQWQIGVWLALSQFQDNRFPLGQYPDEHFTEKPVKEAMAIFRKNLDAISDIIADRNKKLDLPYEYLKPSIIENSVAI

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	86.3
NLMSIM	95.0
AACOMP	93.5
Seqdif (SeqID)	27.1 (XP_003816801.3)
Structdif (F-Target)	3.1 (4nre A)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.579
LOX5 lipoxygenase	0.288
ALOX5	0.048
Arachidonate 5-lipoxygenase-like	0.008
Polyunsaturated fatty acid 5-lipoxygenase	0.005
Arachidonate 5-lipoxygenase a	0.004