MILUP

Prompt

1.1.5.13

Oxidoreductases. Acting on the CH-OH group of donors. With a quinone or similar compound as acceptor. (S)-2-hydroxyglutarate dehydrogenase.

AI Generated Sequence

422 AAs
MSDFVIIGGGIIGMSTAMQLIEVYPDARIPRLIEKSGEACHHTGHEFGVIHSGVYYTPSGLKAQFCLADGNRATTFCDQNGIRYDNCGKMIAATSELEMERMRALWRETAAMNIEREWLSVAELRERTRNITGIGSIFVPSSGILYSREVAEAMAKNFQARGGVIIYNAEVSALSEHANGLVIRRTQQGEYEASTLIGCSGLIPARDLVMLIGEPGFIICPFRGEDFRLAAEHNRIFLHHYIPIPPPAMPFLGVHLTRMIDGSVTGVPNAVLAFKREGYRKRDFSLSDTLEILGSNGIRRVLQNHLLSGLGEMKNSFCKGSLYRLTQVYCPDLSLQDLQPWPAGVRAQAVSPDGKLIDRFLVFATPRTIHTANANSPAATSAIPIGAHVISKVQSTLRESLNPGRTIRAARSVDALHAAFNQ

Ligand/Cofactor

L-2-hydroxyglutarate

C(CC(=O)O)C(C(=O)O)O

Validation Metrics

PLDDT88.0
NLMSIM70.0
AACOMP94.7
Seqdif (SeqID)20.8 (WP_025210776.1)
Structdif (F-Target)5.4 (8w7f C)

ProtNLM

NameScore
L2HG dehydrogenase0.324
L2HG:quinone oxidoreductase0.245
1.1.5.130.198
L-2-hydroxyglutarate dehydrogenase0.124
1.1.3.-0.053
L-2-hydroxyglutarate oxidase0.019
Designed by MP, using an AMD MI250 GPU